
| League | 112 | 50 | 25 | 37 | 187 | 151 | |
| Others | 12 | 4 | 2 | 6 | 13 | 20 | |
| Total | 124 | 54 | 27 | 43 | 200 | 171 |
| League | 61 | 29 | 11 | 21 | 98 | 83 | |
| Others | 5 | 1 | 0 | 4 | 3 | 10 | |
| Total | 66 | 30 | 11 | 25 | 101 | 93 |
| Saturday 28 January 1961 | ||
| FA Cup - 4th Round | ||
| Hillsborough (58,000) | ||
| Sheff Wed | 1 - 1 | Man Utd |
| Cantwell | ||
| Starting XI | ||
| Ronnie Briggs Shay Brennan Noel Cantwell Maurice Setters Bill Foulkes Jimmy Nicholson Dennis Viollet Nobby Stiles Alex Dawson Mark Pearson Bobby Charlton | ||
| Managers | ||
| Harry Catterick | Matt Busby | |
| Ronnie Briggs | 18 | 2 | |
| Shay Brennan | 23 | 69 | |
| Noel Cantwell | 28 | 11 | |
| Maurice Setters | 24 | 47 | |
| Bill Foulkes | 29 | 325 | |
| Jimmy Nicholson | 18 | 30 | |
| Dennis Viollet | 27 | 273 | |
| Nobby Stiles | 19 | 18 | |
| Alex Dawson | 21 | 80 | |
| Mark Pearson | 21 | 44 | |
| Bobby Charlton | 23 | 153 | |
| average age | 23 | - | |
| 1 | Sat 20 Aug 1960 | League Division One | MU | 1 - 3 | Blackburn Rovers | Old Trafford | |
| 2 | Wed 24 Aug 1960 | League Division One | Everton | 4 - 0 | MU | Goodison Park | |
| 3 | Wed 31 Aug 1960 | League Division One | MU | 4 - 0 | Everton | Old Trafford | |
| 4 | Sat 3 Sep 1960 | League Division One | Tottenham Hotspur | 4 - 1 | MU | White Hart Lane | |
| 5 | Mon 5 Sep 1960 | League Division One | West Ham United | 2 - 1 | MU | Upton Park | |
| 6 | Sat 10 Sep 1960 | League Division One | MU | 1 - 1 | Leicester City | Old Trafford | |
| 7 | Wed 14 Sep 1960 | League Division One | MU | 6 - 1 | West Ham United | Old Trafford | |
| 8 | Sat 17 Sep 1960 | League Division One | Aston Villa | 3 - 1 | MU | Villa Park | |
| 9 | Sat 24 Sep 1960 | League Division One | MU | 1 - 3 | Wolverhampton Wanderers | Old Trafford | |
| 10 | Sat 1 Oct 1960 | League Division One | Bolton Wanderers | 1 - 1 | MU | Burnden Park | |
| 11 | Sat 15 Oct 1960 | League Division One | Burnley | 5 - 3 | MU | Turf Moor | |
| 12 | Wed 19 Oct 1960 | League Cup | Exeter City | 1 - 1 | MU | St James' Park | |
| 13 | Sat 22 Oct 1960 | League Division One | MU | 3 - 2 | Newcastle United | Old Trafford | |
| 14 | Mon 24 Oct 1960 | League Division One | MU | 2 - 1 | Nottingham Forest | Old Trafford | |
| 15 | Wed 26 Oct 1960 | League Cup | MU | 4 - 1 | Exeter City | Old Trafford | |
| 16 | Sat 29 Oct 1960 | League Division One | Arsenal | 2 - 1 | MU | Highbury | |
| 17 | Wed 2 Nov 1960 | League Cup | Bradford City | 2 - 1 | MU | Valley Parade | |
| 18 | Sat 5 Nov 1960 | League Division One | MU | 0 - 0 | Sheffield Wednesday | Old Trafford | |
| 19 | Sat 12 Nov 1960 | League Division One | Birmingham City | 3 - 1 | MU | St Andrews | |
| 20 | Sat 19 Nov 1960 | League Division One | MU | 3 - 0 | West Bromwich Albion | Old Trafford | |
| 21 | Sat 26 Nov 1960 | League Division One | Cardiff City | 3 - 0 | MU | Ninian Park | |
| 22 | Sat 3 Dec 1960 | League Division One | MU | 1 - 0 | Preston North End | Old Trafford | |
| 23 | Sat 10 Dec 1960 | League Division One | Fulham | 4 - 4 | MU | Craven Cottage | |
| 24 | Sat 17 Dec 1960 | League Division One | Blackburn Rovers | 1 - 2 | MU | Ewood Park | |
| 25 | Sat 24 Dec 1960 | League Division One | Chelsea | 1 - 2 | MU | Stamford Bridge | |
| 26 | Mon 26 Dec 1960 | League Division One | MU | 6 - 0 | Chelsea | Old Trafford | |
| 27 | Sat 31 Dec 1960 | League Division One | MU | 5 - 1 | Manchester City | Old Trafford | |
| 28 | Sat 7 Jan 1961 | FA Cup | MU | 3 - 0 | Middlesbrough | Old Trafford | |
| 29 | Sat 14 Jan 1961 | League Division One | MU | 2 - 0 | Tottenham Hotspur | Old Trafford | |
| 30 | Sat 21 Jan 1961 | League Division One | Leicester City | 6 - 0 | MU | Filbert Street | |
| 31 | Sat 28 Jan 1961 | FA Cup | Sheffield Wednesday | 1 - 1 | MU | Hillsborough | |
| 32 | Wed 1 Feb 1961 | FA Cup | MU | 2 - 7 | Sheffield Wednesday | Old Trafford | |
| 33 | Sat 4 Feb 1961 | League Division One | MU | 1 - 1 | Aston Villa | Old Trafford | |
| 34 | Sat 11 Feb 1961 | League Division One | Wolverhampton Wanderers | 2 - 1 | MU | Molineux | |
| 35 | Sat 18 Feb 1961 | League Division One | MU | 3 - 1 | Bolton Wanderers | Old Trafford | |
| 36 | Sat 25 Feb 1961 | League Division One | Nottingham Forest | 3 - 2 | MU | City Ground | |
| 37 | Sat 4 Mar 1961 | League Division One | Manchester City | 1 - 3 | MU | Maine Road | |
| 38 | Sat 11 Mar 1961 | League Division One | Newcastle United | 1 - 1 | MU | St James' Park | |
| 39 | Sat 18 Mar 1961 | League Division One | MU | 1 - 1 | Arsenal | Old Trafford | |
| 40 | Sat 25 Mar 1961 | League Division One | Sheffield Wednesday | 5 - 1 | MU | Hillsborough | |
| 41 | Fri 31 Mar 1961 | League Division One | Blackpool | 2 - 0 | MU | Bloomfield Road | |
| 42 | Sat 1 Apr 1961 | League Division One | MU | 3 - 1 | Fulham | Old Trafford | |
| 43 | Mon 3 Apr 1961 | League Division One | MU | 2 - 0 | Blackpool | Old Trafford | |
| 44 | Sat 8 Apr 1961 | League Division One | West Bromwich Albion | 1 - 1 | MU | The Hawthorns | |
| 45 | Wed 12 Apr 1961 | League Division One | MU | 6 - 0 | Burnley | Old Trafford | |
| 46 | Sat 15 Apr 1961 | League Division One | MU | 4 - 1 | Birmingham City | Old Trafford | |
| 47 | Sat 22 Apr 1961 | League Division One | Preston North End | 2 - 4 | MU | Deepdale | |
| 48 | Sat 29 Apr 1961 | League Division One | MU | 3 - 3 | Cardiff City | Old Trafford |
In the tables above and below, where MU * (or NH *) appears in the home team column, it indicates a match played at a neutral venue.
| 1 | Sat 22 Oct 1892 | League Division One | Sheffield Wednesday | 1 - 0 | NH | Olive Grove | |
| 2 | Sat 24 Dec 1892 | League Division One | NH | 1 - 5 | Sheffield Wednesday | North Road | |
| 3 | Sat 16 Sep 1893 | League Division One | Sheffield Wednesday | 0 - 1 | NH | Hillsborough | |
| 4 | Sat 13 Jan 1894 | League Division One | NH | 1 - 2 | Sheffield Wednesday | Bank Street | |
| 5 | Sat 30 Sep 1899 | League Division Two | Sheffield Wednesday | 2 - 1 | NH | Hillsborough | |
| 6 | Sat 3 Feb 1900 | League Division Two | NH | 1 - 0 | Sheffield Wednesday | Bank Street | |
| 7 | Sat 20 Feb 1904 | FA Cup | Sheffield Wednesday | 6 - 0 | MU | Hillsborough | |
| 8 | Sat 17 Nov 1906 | League Division One | Sheffield Wednesday | 5 - 2 | MU | Hillsborough | |
| 9 | Wed 10 Apr 1907 | League Division One | MU | 5 - 0 | Sheffield Wednesday | Bank Street | |
| 10 | Sat 30 Nov 1907 | League Division One | Sheffield Wednesday | 2 - 0 | MU | Hillsborough | |
| 11 | Sat 28 Mar 1908 | League Division One | MU | 4 - 1 | Sheffield Wednesday | Bank Street | |
| 12 | Sat 28 Nov 1908 | League Division One | MU | 3 - 1 | Sheffield Wednesday | Bank Street | |
| 13 | Sat 3 Apr 1909 | League Division One | Sheffield Wednesday | 2 - 0 | MU | Hillsborough | |
| 14 | Sat 25 Dec 1909 | League Division One | MU | 0 - 3 | Sheffield Wednesday | Bank Street | |
| 15 | Mon 27 Dec 1909 | League Division One | Sheffield Wednesday | 4 - 1 | MU | Hillsborough | |
| 16 | Sat 1 Oct 1910 | League Division One | MU | 3 - 2 | Sheffield Wednesday | Old Trafford | |
| 17 | Mon 17 Apr 1911 | League Division One | Sheffield Wednesday | 0 - 0 | MU | Hillsborough | |
| 18 | Sat 7 Oct 1911 | League Division One | MU | 3 - 1 | Sheffield Wednesday | Old Trafford | |
| 19 | Sat 10 Feb 1912 | League Division One | Sheffield Wednesday | 3 - 0 | MU | Hillsborough | |
| 20 | Sat 28 Sep 1912 | League Division One | Sheffield Wednesday | 3 - 3 | MU | Hillsborough | |
| 21 | Sat 25 Jan 1913 | League Division One | MU | 2 - 0 | Sheffield Wednesday | Old Trafford | |
| 22 | Sat 6 Sep 1913 | League Division One | Sheffield Wednesday | 1 - 3 | MU | Hillsborough | |
| 23 | Sat 27 Dec 1913 | League Division One | MU | 2 - 1 | Sheffield Wednesday | Old Trafford | |
| 24 | Sat 10 Oct 1914 | League Division One | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 25 | Sat 9 Jan 1915 | FA Cup | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 26 | Sat 13 Feb 1915 | League Division One | MU | 2 - 0 | Sheffield Wednesday | Old Trafford | |
| 27 | Mon 1 Sep 1919 | League Division One | MU | 0 - 0 | Sheffield Wednesday | Old Trafford | |
| 28 | Mon 8 Sep 1919 | League Division One | Sheffield Wednesday | 1 - 3 | MU | Hillsborough | |
| 29 | Mon 28 Aug 1922 | League Division Two | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 30 | Mon 4 Sep 1922 | League Division Two | MU | 1 - 0 | Sheffield Wednesday | Old Trafford | |
| 31 | Sat 26 Apr 1924 | League Division Two | MU | 2 - 0 | Sheffield Wednesday | Old Trafford | |
| 32 | Sat 3 May 1924 | League Division Two | Sheffield Wednesday | 2 - 0 | MU | Hillsborough | |
| 33 | Sat 27 Sep 1924 | League Division Two | MU | 2 - 0 | Sheffield Wednesday | Old Trafford | |
| 34 | Sat 10 Jan 1925 | FA Cup | Sheffield Wednesday | 2 - 0 | MU | Hillsborough | |
| 35 | Mon 23 Feb 1925 | League Division Two | Sheffield Wednesday | 1 - 1 | MU | Hillsborough | |
| 36 | Sat 6 Nov 1926 | League Division One | MU | 0 - 0 | Sheffield Wednesday | Old Trafford | |
| 37 | Sat 26 Mar 1927 | League Division One | Sheffield Wednesday | 2 - 0 | MU | Hillsborough | |
| 38 | Mon 29 Aug 1927 | League Division One | Sheffield Wednesday | 0 - 2 | MU | Hillsborough | |
| 39 | Wed 7 Sep 1927 | League Division One | MU | 1 - 1 | Sheffield Wednesday | Old Trafford | |
| 40 | Sat 10 Nov 1928 | League Division One | Sheffield Wednesday | 2 - 1 | MU | Hillsborough | |
| 41 | Sat 23 Mar 1929 | League Division One | MU | 2 - 1 | Sheffield Wednesday | Old Trafford | |
| 42 | Sat 16 Nov 1929 | League Division One | Sheffield Wednesday | 7 - 2 | MU | Hillsborough | |
| 43 | Mon 14 Apr 1930 | League Division One | MU | 2 - 2 | Sheffield Wednesday | Old Trafford | |
| 44 | Sat 20 Sep 1930 | League Division One | Sheffield Wednesday | 3 - 0 | MU | Hillsborough | |
| 45 | Wed 28 Jan 1931 | League Division One | MU | 4 - 1 | Sheffield Wednesday | Old Trafford | |
| 46 | Sat 19 Sep 1936 | League Division One | MU | 1 - 1 | Sheffield Wednesday | Old Trafford | |
| 47 | Sat 23 Jan 1937 | League Division One | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 48 | Sat 23 Oct 1937 | League Division Two | MU | 1 - 0 | Sheffield Wednesday | Old Trafford | |
| 49 | Sat 5 Mar 1938 | League Division Two | Sheffield Wednesday | 1 - 3 | MU | Hillsborough | |
| 50 | Sat 7 Oct 1950 | League Division One | MU | 3 - 1 | Sheffield Wednesday | Old Trafford | |
| 51 | Mon 26 Feb 1951 | League Division One | Sheffield Wednesday | 0 - 4 | MU | Hillsborough | |
| 52 | Sat 8 Nov 1952 | League Division One | MU | 1 - 1 | Sheffield Wednesday | Old Trafford | |
| 53 | Sat 28 Mar 1953 | League Division One | Sheffield Wednesday | 0 - 0 | MU | Hillsborough | |
| 54 | Fri 25 Dec 1953 | League Division One | MU | 5 - 2 | Sheffield Wednesday | Old Trafford | |
| 55 | Sat 26 Dec 1953 | League Division One | Sheffield Wednesday | 0 - 1 | MU | Hillsborough | |
| 56 | Mon 23 Aug 1954 | League Division One | Sheffield Wednesday | 2 - 4 | MU | Hillsborough | |
| 57 | Wed 1 Sep 1954 | League Division One | MU | 2 - 0 | Sheffield Wednesday | Old Trafford | |
| 58 | Sat 15 Sep 1956 | League Division One | MU | 4 - 1 | Sheffield Wednesday | Old Trafford | |
| 59 | Sat 19 Jan 1957 | League Division One | Sheffield Wednesday | 2 - 1 | MU | Hillsborough | |
| 60 | Sat 16 Nov 1957 | League Division One | MU | 2 - 1 | Sheffield Wednesday | Old Trafford | |
| 61 | Wed 19 Feb 1958 | FA Cup | MU | 3 - 0 | Sheffield Wednesday | Old Trafford | |
| 62 | Sat 29 Mar 1958 | League Division One | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 63 | Sat 24 Oct 1959 | League Division One | MU | 3 - 1 | Sheffield Wednesday | Old Trafford | |
| 64 | Sat 20 Feb 1960 | FA Cup | MU | 0 - 1 | Sheffield Wednesday | Old Trafford | |
| 65 | Wed 30 Mar 1960 | League Division One | Sheffield Wednesday | 4 - 2 | MU | Hillsborough | |
| 66 | Sat 5 Nov 1960 | League Division One | MU | 0 - 0 | Sheffield Wednesday | Old Trafford | |
| 67 | Sat 28 Jan 1961 | FA Cup | Sheffield Wednesday | 1 - 1 | MU | Hillsborough | |
| 68 | Wed 1 Feb 1961 | FA Cup | MU | 2 - 7 | Sheffield Wednesday | Old Trafford | |
| 69 | Sat 25 Mar 1961 | League Division One | Sheffield Wednesday | 5 - 1 | MU | Hillsborough | |
| 70 | Sat 4 Nov 1961 | League Division One | Sheffield Wednesday | 3 - 1 | MU | Hillsborough | |
| 71 | Sat 17 Feb 1962 | FA Cup | MU | 0 - 0 | Sheffield Wednesday | Old Trafford | |
| 72 | Wed 21 Feb 1962 | FA Cup | Sheffield Wednesday | 0 - 2 | MU | Hillsborough | |
| 73 | Sat 24 Mar 1962 | League Division One | MU | 1 - 1 | Sheffield Wednesday | Old Trafford | |
| 74 | Sat 29 Sep 1962 | League Division One | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 75 | Wed 1 May 1963 | League Division One | MU | 1 - 3 | Sheffield Wednesday | Old Trafford | |
| 76 | Sat 24 Aug 1963 | League Division One | Sheffield Wednesday | 3 - 3 | MU | Hillsborough | |
| 77 | Sat 14 Dec 1963 | League Division One | MU | 3 - 1 | Sheffield Wednesday | Old Trafford | |
| 78 | Sat 7 Nov 1964 | League Division One | MU | 1 - 0 | Sheffield Wednesday | Old Trafford | |
| 79 | Sat 20 Mar 1965 | League Division One | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 80 | Sat 21 Aug 1965 | League Division One | MU | 1 - 0 | Sheffield Wednesday | Old Trafford | |
| 81 | Sat 29 Jan 1966 | League Division One | Sheffield Wednesday | 0 - 0 | MU | Hillsborough | |
| 82 | Sat 12 Nov 1966 | League Division One | MU | 2 - 0 | Sheffield Wednesday | Old Trafford | |
| 83 | Mon 10 Apr 1967 | League Division One | Sheffield Wednesday | 2 - 2 | MU | Hillsborough | |
| 84 | Sat 16 Sep 1967 | League Division One | Sheffield Wednesday | 1 - 1 | MU | Hillsborough | |
| 85 | Sat 20 Jan 1968 | League Division One | MU | 4 - 2 | Sheffield Wednesday | Old Trafford | |
| 86 | Sat 31 Aug 1968 | League Division One | Sheffield Wednesday | 5 - 4 | MU | Hillsborough | |
| 87 | Sat 22 Mar 1969 | League Division One | MU | 1 - 0 | Sheffield Wednesday | Old Trafford | |
| 88 | Wed 17 Sep 1969 | League Division One | Sheffield Wednesday | 1 - 3 | MU | Hillsborough | |
| 89 | Wed 15 Apr 1970 | League Division One | MU | 2 - 2 | Sheffield Wednesday | Old Trafford | |
| 90 | Sat 7 Dec 1974 | League Division Two | Sheffield Wednesday | 4 - 4 | MU | Hillsborough | |
| 91 | Sat 11 Jan 1975 | League Division Two | MU | 2 - 0 | Sheffield Wednesday | Old Trafford | |
| 92 | Tue 1 Jan 1985 | League Division One | MU | 1 - 2 | Sheffield Wednesday | Old Trafford | |
| 93 | Tue 9 Apr 1985 | League Division One | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 94 | Sat 9 Nov 1985 | League Division One | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 95 | Sun 13 Apr 1986 | League Division One | MU | 0 - 2 | Sheffield Wednesday | Old Trafford | |
| 96 | Sat 11 Oct 1986 | League Division One | MU | 3 - 1 | Sheffield Wednesday | Old Trafford | |
| 97 | Sat 21 Mar 1987 | League Division One | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 98 | Sat 10 Oct 1987 | League Division One | Sheffield Wednesday | 2 - 4 | MU | Hillsborough | |
| 99 | Sat 12 Mar 1988 | League Division One | MU | 4 - 1 | Sheffield Wednesday | Old Trafford | |
| 100 | Wed 23 Nov 1988 | League Division One | MU | 1 - 1 | Sheffield Wednesday | Old Trafford | |
| 101 | Sat 11 Feb 1989 | League Division One | Sheffield Wednesday | 0 - 2 | MU | Hillsborough | |
| 102 | Sat 14 Oct 1989 | League Division One | MU | 0 - 0 | Sheffield Wednesday | Old Trafford | |
| 103 | Wed 21 Mar 1990 | League Division One | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 104 | Sun 21 Apr 1991 | League Cup | MU * | 0 - 1 | Sheffield Wednesday | Wembley | |
| 105 | Sat 26 Oct 1991 | League Division One | Sheffield Wednesday | 3 - 2 | MU | Hillsborough | |
| 106 | Sat 8 Feb 1992 | League Division One | MU | 1 - 1 | Sheffield Wednesday | Old Trafford | |
| 107 | Sat 26 Dec 1992 | Premiership | Sheffield Wednesday | 3 - 3 | MU | Hillsborough | |
| 108 | Sat 10 Apr 1993 | Premiership | MU | 2 - 1 | Sheffield Wednesday | Old Trafford | |
| 109 | Sat 2 Oct 1993 | Premiership | Sheffield Wednesday | 2 - 3 | MU | Hillsborough | |
| 110 | Sun 13 Feb 1994 | League Cup | MU | 1 - 0 | Sheffield Wednesday | Old Trafford | |
| 111 | Wed 2 Mar 1994 | League Cup | Sheffield Wednesday | 1 - 4 | MU | Hillsborough | |
| 112 | Wed 16 Mar 1994 | Premiership | MU | 5 - 0 | Sheffield Wednesday | Old Trafford | |
| 113 | Sat 8 Oct 1994 | Premiership | Sheffield Wednesday | 1 - 0 | MU | Hillsborough | |
| 114 | Sun 7 May 1995 | Premiership | MU | 1 - 0 | Sheffield Wednesday | Old Trafford | |
| 115 | Sat 23 Sep 1995 | Premiership | Sheffield Wednesday | 0 - 0 | MU | Hillsborough | |
| 116 | Sat 9 Dec 1995 | Premiership | MU | 2 - 2 | Sheffield Wednesday | Old Trafford | |
| 117 | Wed 18 Dec 1996 | Premiership | Sheffield Wednesday | 1 - 1 | MU | Hillsborough | |
| 118 | Sat 15 Mar 1997 | Premiership | MU | 2 - 0 | Sheffield Wednesday | Old Trafford | |
| 119 | Sat 1 Nov 1997 | Premiership | MU | 6 - 1 | Sheffield Wednesday | Old Trafford | |
| 120 | Sat 7 Mar 1998 | Premiership | Sheffield Wednesday | 2 - 0 | MU | Hillsborough | |
| 121 | Sat 21 Nov 1998 | Premiership | Sheffield Wednesday | 3 - 1 | MU | Hillsborough | |
| 122 | Sat 17 Apr 1999 | Premiership | MU | 3 - 0 | Sheffield Wednesday | Old Trafford | |
| 123 | Wed 11 Aug 1999 | Premiership | MU | 4 - 0 | Sheffield Wednesday | Old Trafford | |
| 124 | Wed 2 Feb 2000 | Premiership | Sheffield Wednesday | 0 - 1 | MU | Hillsborough |