| League | 58 | 28 | 13 | 17 | 91 | 60 | |
| Others | 17 | 9 | 5 | 3 | 30 | 21 | |
| Total | 75 | 37 | 18 | 20 | 121 | 81 |
| League | 57 | 27 | 13 | 17 | 86 | 60 | |
| Others | 17 | 9 | 5 | 3 | 30 | 21 | |
| Total | 74 | 36 | 18 | 20 | 116 | 81 |
| Saturday 6 February 2010 | ||
| Premiership | ||
| Old Trafford (74,684) | ||
| Man Utd | 5 - 0 | Portsmouth |
| Rooney 40 og 45 og 59 Berbatov 62 og 69 | ||
| Starting XI | ||
| Edwin van der Sar Gary Neville Wes Brown Jonny Evans Patrice Evra Antonio Valencia Darren Fletchersub 66 Michael Carrick Luis Nani Dimitar Berbatovsub 66 Wayne Rooneysub 66 | David James Anthony Vanden Borre Tal Ben-Haim Marc Wilson Ricardo Rocha Danny Webber Richard Hughes Jamie O'Hara Hayden Mullins Nadir Belhadj Frederic Piquionne | |
| Substitutes | ||
| Michael Owen66 Darron Gibson66 Mame Biram Diouf66 | Kevin-Prince Boateng Owusu-Abeyie Quincy Hassan Yebda | |
| Managers | ||
| Alex Ferguson | Avram Grant | |
| Referee | ||
| Lee Mason | ||
| Edwin van der Sar | 39 | 204 | |
| Gary Neville | 35 | 585 | |
| Wes Brown | 30 | 342 | |
| Jonny Evans | 22 | 57 | |
| Patrice Evra | 28 | 179 | |
| Antonio Valencia | 24 | 33 | |
| Darren Fletcher | 26 | 240 | |
| Michael Carrick | 28 | 176 | |
| Luis Nani | 23 | 91 | |
| Dimitar Berbatov | 29 | 70 | |
| Wayne Rooney | 24 | 269 | |
| Mame Biram Diouf | 22 | 4 | |
| Darron Gibson | 22 | 28 | |
| Michael Owen | 30 | 28 | |
| average age | 27 | - | |
| 1 | Sun 9 Aug 2009 | FA Charity Shield | MU * | 2 - 2 | Chelsea | Wembley | |
| 2 | Sun 16 Aug 2009 | Premiership | MU | 1 - 0 | Birmingham City | Old Trafford | |
| 3 | Wed 19 Aug 2009 | Premiership | Burnley | 1 - 0 | MU | Turf Moor | |
| 4 | Sat 22 Aug 2009 | Premiership | Wigan Athletic | 0 - 5 | MU | JJB Stadium | |
| 5 | Sat 29 Aug 2009 | Premiership | MU | 2 - 1 | Arsenal | Old Trafford | |
| 6 | Sat 12 Sep 2009 | Premiership | Tottenham Hotspur | 1 - 3 | MU | White Hart Lane | |
| 7 | Tue 15 Sep 2009 | UEFA Champions League | Besiktas | 0 - 1 | MU | BJK Inonu Stadium | |
| 8 | Sun 20 Sep 2009 | Premiership | MU | 4 - 3 | Manchester City | Old Trafford | |
| 9 | Wed 23 Sep 2009 | League Cup | MU | 1 - 0 | Wolverhampton Wanderers | Old Trafford | |
| 10 | Sat 26 Sep 2009 | Premiership | Stoke City | 0 - 2 | MU | Britannia Stadium | |
| 11 | Wed 30 Sep 2009 | UEFA Champions League | MU | 2 - 1 | VfL Wolfsburg | Old Trafford | |
| 12 | Sat 3 Oct 2009 | Premiership | MU | 2 - 2 | Sunderland | Old Trafford | |
| 13 | Sat 17 Oct 2009 | Premiership | MU | 2 - 1 | Bolton Wanderers | Old Trafford | |
| 14 | Wed 21 Oct 2009 | UEFA Champions League | CSKA Moscow | 0 - 1 | MU | Luzhniki Stadium | |
| 15 | Sun 25 Oct 2009 | Premiership | Liverpool | 2 - 0 | MU | Anfield | |
| 16 | Tue 27 Oct 2009 | League Cup | Barnsley | 0 - 2 | MU | Oakwell | |
| 17 | Sat 31 Oct 2009 | Premiership | MU | 2 - 0 | Blackburn Rovers | Old Trafford | |
| 18 | Tue 3 Nov 2009 | UEFA Champions League | MU | 3 - 3 | CSKA Moscow | Old Trafford | |
| 19 | Sun 8 Nov 2009 | Premiership | Chelsea | 1 - 0 | MU | Stamford Bridge | |
| 20 | Sat 21 Nov 2009 | Premiership | MU | 3 - 0 | Everton | Old Trafford | |
| 21 | Wed 25 Nov 2009 | UEFA Champions League | MU | 0 - 1 | Besiktas | Old Trafford | |
| 22 | Sat 28 Nov 2009 | Premiership | Portsmouth | 1 - 4 | MU | Fratton Park | |
| 23 | Tue 1 Dec 2009 | League Cup | MU | 2 - 0 | Tottenham Hotspur | Old Trafford | |
| 24 | Sat 5 Dec 2009 | Premiership | West Ham United | 0 - 4 | MU | Upton Park | |
| 25 | Tue 8 Dec 2009 | UEFA Champions League | VfL Wolfsburg | 1 - 3 | MU | Volkswagen Arena | |
| 26 | Sat 12 Dec 2009 | Premiership | MU | 0 - 1 | Aston Villa | Old Trafford | |
| 27 | Tue 15 Dec 2009 | Premiership | MU | 3 - 0 | Wolverhampton Wanderers | Old Trafford | |
| 28 | Sat 19 Dec 2009 | Premiership | Fulham | 3 - 0 | MU | Craven Cottage | |
| 29 | Sun 27 Dec 2009 | Premiership | Hull City | 1 - 3 | MU | KC Stadium | |
| 30 | Wed 30 Dec 2009 | Premiership | MU | 5 - 0 | Wigan Athletic | Old Trafford | |
| 31 | Sun 3 Jan 2010 | FA Cup | MU | 0 - 1 | Leeds United | Old Trafford | |
| 32 | Sat 9 Jan 2010 | Premiership | Birmingham City | 1 - 1 | MU | St Andrews | |
| 33 | Sat 16 Jan 2010 | Premiership | MU | 3 - 0 | Burnley | Old Trafford | |
| 34 | Tue 19 Jan 2010 | League Cup | Manchester City | 2 - 1 | MU | City of Manchester Stadium | |
| 35 | Sat 23 Jan 2010 | Premiership | MU | 4 - 0 | Hull City | Old Trafford | |
| 36 | Wed 27 Jan 2010 | League Cup | MU | 3 - 1 | Manchester City | Old Trafford | |
| 37 | Sun 31 Jan 2010 | Premiership | Arsenal | 1 - 3 | MU | Emirates Stadium | |
| 38 | Sat 6 Feb 2010 | Premiership | MU | 5 - 0 | Portsmouth | Old Trafford | |
| 39 | Wed 10 Feb 2010 | Premiership | Aston Villa | 1 - 1 | MU | Villa Park | |
| 40 | Tue 16 Feb 2010 | UEFA Champions League | AC Milan | 2 - 3 | MU | Stadio San Siro | |
| 41 | Sat 20 Feb 2010 | Premiership | Everton | 3 - 1 | MU | Goodison Park | |
| 42 | Tue 23 Feb 2010 | Premiership | MU | 3 - 0 | West Ham United | Old Trafford | |
| 43 | Sun 28 Feb 2010 | League Cup | MU * | 2 - 1 | Aston Villa | Wembley | |
| 44 | Sat 6 Mar 2010 | Premiership | Wolverhampton Wanderers | 0 - 1 | MU | Molineux | |
| 45 | Wed 10 Mar 2010 | UEFA Champions League | MU | 4 - 0 | AC Milan | Old Trafford |
In the tables above and below, where MU * (or NH *) appears in the home team column, it indicates a match played at a neutral venue.
| 1 | Sat 5 Jan 1901 | FA Cup | NH | 3 - 0 | Portsmouth | Bank Street | |
| 2 | Sat 12 Jan 1907 | FA Cup | Portsmouth | 2 - 2 | MU | Fratton Park | |
| 3 | Wed 16 Jan 1907 | FA Cup | MU | 1 - 2 | Portsmouth | Bank Street | |
| 4 | Sat 8 Nov 1924 | League Division Two | Portsmouth | 1 - 1 | MU | Fratton Park | |
| 5 | Sat 14 Mar 1925 | League Division Two | MU | 2 - 0 | Portsmouth | Old Trafford | |
| 6 | Sat 5 Nov 1927 | League Division One | MU | 2 - 0 | Portsmouth | Old Trafford | |
| 7 | Sat 17 Mar 1928 | League Division One | Portsmouth | 1 - 0 | MU | Fratton Park | |
| 8 | Sat 22 Dec 1928 | League Division One | Portsmouth | 3 - 0 | MU | Fratton Park | |
| 9 | Sat 4 May 1929 | League Division One | MU | 0 - 0 | Portsmouth | Old Trafford | |
| 10 | Sat 19 Oct 1929 | League Division One | Portsmouth | 3 - 0 | MU | Fratton Park | |
| 11 | Sat 22 Feb 1930 | League Division One | MU | 3 - 0 | Portsmouth | Old Trafford | |
| 12 | Sat 25 Oct 1930 | League Division One | Portsmouth | 4 - 1 | MU | Fratton Park | |
| 13 | Mon 16 Mar 1931 | League Division One | MU | 0 - 1 | Portsmouth | Old Trafford | |
| 14 | Sat 13 Jan 1934 | FA Cup | MU | 1 - 1 | Portsmouth | Old Trafford | |
| 15 | Wed 17 Jan 1934 | FA Cup | Portsmouth | 4 - 1 | MU | Fratton Park | |
| 16 | Sat 17 Oct 1936 | League Division One | Portsmouth | 2 - 1 | MU | Fratton Park | |
| 17 | Sat 20 Feb 1937 | League Division One | MU | 0 - 1 | Portsmouth | Old Trafford | |
| 18 | Sat 3 Dec 1938 | League Division One | Portsmouth | 0 - 0 | MU | Fratton Park | |
| 19 | Sat 8 Apr 1939 | League Division One | MU | 1 - 1 | Portsmouth | Old Trafford | |
| 20 | Sat 26 Apr 1947 | League Division One | Portsmouth | 0 - 1 | MU | Fratton Park | |
| 21 | Sat 17 May 1947 | League Division One | MU | 3 - 0 | Portsmouth | Maine Road | |
| 22 | Thu 25 Dec 1947 | League Division One | MU | 3 - 2 | Portsmouth | Maine Road | |
| 23 | Sat 27 Dec 1947 | League Division One | Portsmouth | 1 - 3 | MU | Fratton Park | |
| 24 | Sat 11 Dec 1948 | League Division One | Portsmouth | 2 - 2 | MU | Fratton Park | |
| 25 | Sat 7 May 1949 | League Division One | MU | 3 - 2 | Portsmouth | Maine Road | |
| 26 | Sat 29 Oct 1949 | League Division One | Portsmouth | 0 - 0 | MU | Fratton Park | |
| 27 | Sat 11 Feb 1950 | FA Cup | MU | 3 - 3 | Portsmouth | Old Trafford | |
| 28 | Wed 15 Feb 1950 | FA Cup | Portsmouth | 1 - 3 | MU | Fratton Park | |
| 29 | Sat 15 Apr 1950 | League Division One | MU | 0 - 2 | Portsmouth | Old Trafford | |
| 30 | Sat 21 Oct 1950 | League Division One | MU | 0 - 0 | Portsmouth | Old Trafford | |
| 31 | Sat 10 Mar 1951 | League Division One | Portsmouth | 0 - 0 | MU | Fratton Park | |
| 32 | Sat 17 Nov 1951 | League Division One | MU | 1 - 3 | Portsmouth | Old Trafford | |
| 33 | Sat 5 Apr 1952 | League Division One | Portsmouth | 1 - 0 | MU | Fratton Park | |
| 34 | Sat 6 Sep 1952 | League Division One | Portsmouth | 2 - 0 | MU | Fratton Park | |
| 35 | Sat 17 Jan 1953 | League Division One | MU | 1 - 0 | Portsmouth | Old Trafford | |
| 36 | Sat 28 Nov 1953 | League Division One | Portsmouth | 1 - 1 | MU | Fratton Park | |
| 37 | Sat 17 Apr 1954 | League Division One | MU | 2 - 0 | Portsmouth | Old Trafford | |
| 38 | Sat 21 Aug 1954 | League Division One | MU | 1 - 3 | Portsmouth | Old Trafford | |
| 39 | Sat 18 Dec 1954 | League Division One | Portsmouth | 0 - 0 | MU | Fratton Park | |
| 40 | Sat 10 Dec 1955 | League Division One | Portsmouth | 3 - 2 | MU | Fratton Park | |
| 41 | Sat 21 Apr 1956 | League Division One | MU | 1 - 0 | Portsmouth | Old Trafford | |
| 42 | Sat 1 Sep 1956 | League Division One | MU | 3 - 0 | Portsmouth | Old Trafford | |
| 43 | Sat 29 Dec 1956 | League Division One | Portsmouth | 1 - 3 | MU | Fratton Park | |
| 44 | Sat 19 Oct 1957 | League Division One | MU | 0 - 3 | Portsmouth | Old Trafford | |
| 45 | Wed 16 Apr 1958 | League Division One | Portsmouth | 3 - 3 | MU | Fratton Park | |
| 46 | Fri 27 Mar 1959 | League Division One | MU | 6 - 1 | Portsmouth | Old Trafford | |
| 47 | Mon 30 Mar 1959 | League Division One | Portsmouth | 1 - 3 | MU | Fratton Park | |
| 48 | Wed 7 Oct 1970 | League Cup | MU | 1 - 0 | Portsmouth | Old Trafford | |
| 49 | Wed 28 Aug 1974 | League Division Two | MU | 2 - 1 | Portsmouth | Old Trafford | |
| 50 | Tue 15 Oct 1974 | League Division Two | Portsmouth | 0 - 0 | MU | Fratton Park | |
| 51 | Sat 19 Dec 1987 | League Division One | Portsmouth | 1 - 2 | MU | Fratton Park | |
| 52 | Sat 7 May 1988 | League Division One | MU | 4 - 1 | Portsmouth | Old Trafford | |
| 53 | Wed 20 Sep 1989 | League Cup | Portsmouth | 2 - 3 | MU | Fratton Park | |
| 54 | Tue 3 Oct 1989 | League Cup | MU | 0 - 0 | Portsmouth | Old Trafford | |
| 55 | Wed 30 Oct 1991 | League Cup | MU | 3 - 1 | Portsmouth | Old Trafford | |
| 56 | Wed 12 Jan 1994 | League Cup | MU | 2 - 2 | Portsmouth | Old Trafford | |
| 57 | Wed 26 Jan 1994 | League Cup | Portsmouth | 0 - 1 | MU | Fratton Park | |
| 58 | Sat 4 Jan 2003 | FA Cup | MU | 4 - 1 | Portsmouth | Old Trafford | |
| 59 | Sat 1 Nov 2003 | Premiership | MU | 3 - 0 | Portsmouth | Old Trafford | |
| 60 | Sat 17 Apr 2004 | Premiership | Portsmouth | 1 - 0 | MU | Fratton Park | |
| 61 | Sat 30 Oct 2004 | Premiership | Portsmouth | 2 - 0 | MU | Fratton Park | |
| 62 | Sat 26 Feb 2005 | Premiership | MU | 2 - 1 | Portsmouth | Old Trafford | |
| 63 | Sat 3 Dec 2005 | Premiership | MU | 3 - 0 | Portsmouth | Old Trafford | |
| 64 | Sat 11 Feb 2006 | Premiership | Portsmouth | 1 - 3 | MU | Fratton Park | |
| 65 | Sat 4 Nov 2006 | Premiership | MU | 3 - 0 | Portsmouth | Old Trafford | |
| 66 | Sat 27 Jan 2007 | FA Cup | MU | 2 - 1 | Portsmouth | Old Trafford | |
| 67 | Sat 7 Apr 2007 | Premiership | Portsmouth | 2 - 1 | MU | Fratton Park | |
| 68 | Wed 15 Aug 2007 | Premiership | Portsmouth | 1 - 1 | MU | Fratton Park | |
| 69 | Wed 30 Jan 2008 | Premiership | MU | 2 - 0 | Portsmouth | Old Trafford | |
| 70 | Sat 8 Mar 2008 | FA Cup | MU | 0 - 1 | Portsmouth | Old Trafford | |
| 71 | Sun 10 Aug 2008 | FA Charity Shield | MU * | 0 - 0 | Portsmouth | Wembley | |
| 72 | Mon 25 Aug 2008 | Premiership | Portsmouth | 0 - 1 | MU | Fratton Park | |
| 73 | Wed 22 Apr 2009 | Premiership | MU | 2 - 0 | Portsmouth | Old Trafford | |
| 74 | Sat 28 Nov 2009 | Premiership | Portsmouth | 1 - 4 | MU | Fratton Park | |
| 75 | Sat 6 Feb 2010 | Premiership | MU | 5 - 0 | Portsmouth | Old Trafford |