Manchester United vs Southampton - 4 Nov 1978
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| League | 90 | 46 | 21 | 23 | 155 | 103 | |
| Others | 19 | 10 | 6 | 3 | 35 | 19 | |
| Total | 109 | 56 | 27 | 26 | 190 | 122 |
| League | 36 | 16 | 8 | 12 | 59 | 43 | |
| Others | 9 | 5 | 3 | 1 | 17 | 10 | |
| Total | 45 | 21 | 11 | 13 | 76 | 53 |
| Saturday 4 November 1978 | ||
| League Division One | ||
| Old Trafford (46,259) | ||
| Man Utd | 1 - 1 | S'mpton |
| Greenhoff | ||
| Starting XI | ||
| Paddy Roche Jimmy Nicholl Stewart Houston Sammy McIlroy Brian Greenhoff Martin Buchan Steve Coppell Jimmy Greenhoff Joe Jordan Lou Macari Ashley Grimes | ||
| Managers | ||
| Dave Sexton | Lawrie McMenemy | |
| Paddy Roche | 27 | 47 | |
| Jimmy Nicholl | 21 | 131 | |
| Stewart Houston | 28 | 216 | |
| Sammy McIlroy | 24 | 287 | |
| Brian Greenhoff | 25 | 244 | |
| Martin Buchan | 29 | 308 | |
| Steve Coppell | 23 | 182 | |
| Jimmy Greenhoff | 32 | 77 | |
| Joe Jordan | 26 | 31 | |
| Lou Macari | 29 | 253 | |
| Ashley Grimes | 21 | 26 | |
| average age | 26 | - | |
| 1 | Sat 19 Aug 1978 | League Division One | MU | 1 - 0 | Birmingham City | Old Trafford | |
| 2 | Wed 23 Aug 1978 | League Division One | Leeds United | 2 - 3 | MU | Elland Road | |
| 3 | Sat 26 Aug 1978 | League Division One | Ipswich Town | 3 - 0 | MU | Portman Road | |
| 4 | Wed 30 Aug 1978 | League Cup | Stockport County | 2 - 3 | MU | Old Trafford | |
| 5 | Sat 2 Sep 1978 | League Division One | MU | 1 - 1 | Everton | Old Trafford | |
| 6 | Sat 9 Sep 1978 | League Division One | Queens Park Rangers | 1 - 1 | MU | Loftus Road | |
| 7 | Sat 16 Sep 1978 | League Division One | MU | 1 - 1 | Nottingham Forest | Old Trafford | |
| 8 | Sat 23 Sep 1978 | League Division One | Arsenal | 1 - 1 | MU | Highbury | |
| 9 | Sat 30 Sep 1978 | League Division One | MU | 1 - 0 | Manchester City | Old Trafford | |
| 10 | Wed 4 Oct 1978 | League Cup | MU | 1 - 2 | Watford | Old Trafford | |
| 11 | Sat 7 Oct 1978 | League Division One | MU | 3 - 2 | Middlesbrough | Old Trafford | |
| 12 | Sat 14 Oct 1978 | League Division One | Aston Villa | 2 - 2 | MU | Villa Park | |
| 13 | Sat 21 Oct 1978 | League Division One | MU | 1 - 3 | Bristol City | Old Trafford | |
| 14 | Sat 28 Oct 1978 | League Division One | Wolverhampton Wanderers | 2 - 4 | MU | Molineux | |
| 15 | Sat 4 Nov 1978 | League Division One | MU | 1 - 1 | Southampton | Old Trafford | |
| 16 | Sat 11 Nov 1978 | League Division One | Birmingham City | 5 - 1 | MU | St Andrews | |
| 17 | Sat 18 Nov 1978 | League Division One | MU | 2 - 0 | Ipswich Town | Old Trafford | |
| 18 | Tue 21 Nov 1978 | League Division One | Everton | 3 - 0 | MU | Goodison Park | |
| 19 | Sat 25 Nov 1978 | League Division One | Chelsea | 0 - 1 | MU | Stamford Bridge | |
| 20 | Sat 9 Dec 1978 | League Division One | Derby County | 1 - 3 | MU | The Baseball Ground | |
| 21 | Sat 16 Dec 1978 | League Division One | MU | 2 - 0 | Tottenham Hotspur | Old Trafford | |
| 22 | Fri 22 Dec 1978 | League Division One | Bolton Wanderers | 3 - 0 | MU | Burnden Park | |
| 23 | Tue 26 Dec 1978 | League Division One | MU | 0 - 3 | Liverpool | Old Trafford | |
| 24 | Sat 30 Dec 1978 | League Division One | MU | 3 - 5 | West Bromwich Albion | Old Trafford | |
| 25 | Mon 15 Jan 1979 | FA Cup | MU | 3 - 0 | Chelsea | Old Trafford | |
| 26 | Wed 31 Jan 1979 | FA Cup | Fulham | 1 - 1 | MU | Craven Cottage | |
| 27 | Sat 3 Feb 1979 | League Division One | MU | 0 - 2 | Arsenal | Old Trafford | |
| 28 | Sat 10 Feb 1979 | League Division One | Manchester City | 0 - 3 | MU | Maine Road | |
| 29 | Mon 12 Feb 1979 | FA Cup | MU | 1 - 0 | Fulham | Old Trafford | |
| 30 | Tue 20 Feb 1979 | FA Cup | Colchester United | 0 - 1 | MU | Layer Road | |
| 31 | Sat 24 Feb 1979 | League Division One | MU | 1 - 1 | Aston Villa | Old Trafford | |
| 32 | Wed 28 Feb 1979 | League Division One | MU | 2 - 0 | Queens Park Rangers | Old Trafford | |
| 33 | Sat 3 Mar 1979 | League Division One | Bristol City | 1 - 2 | MU | Ashton Gate | |
| 34 | Sat 10 Mar 1979 | FA Cup | Tottenham Hotspur | 1 - 1 | MU | White Hart Lane | |
| 35 | Wed 14 Mar 1979 | FA Cup | MU | 2 - 0 | Tottenham Hotspur | Old Trafford | |
| 36 | Tue 20 Mar 1979 | League Division One | Coventry City | 4 - 3 | MU | Highfield Road | |
| 37 | Sat 24 Mar 1979 | League Division One | MU | 4 - 1 | Leeds United | Old Trafford | |
| 38 | Tue 27 Mar 1979 | League Division One | Middlesbrough | 2 - 2 | MU | Ayresome Park | |
| 39 | Sat 31 Mar 1979 | FA Cup | MU * | 2 - 2 | Liverpool | Maine Road | |
| 40 | Wed 4 Apr 1979 | FA Cup | MU * | 1 - 0 | Liverpool | Goodison Park | |
| 41 | Sat 7 Apr 1979 | League Division One | Norwich City | 2 - 2 | MU | Carrow Road | |
| 42 | Wed 11 Apr 1979 | League Division One | MU | 1 - 2 | Bolton Wanderers | Old Trafford | |
| 43 | Sat 14 Apr 1979 | League Division One | Liverpool | 2 - 0 | MU | Anfield | |
| 44 | Mon 16 Apr 1979 | League Division One | MU | 0 - 0 | Coventry City | Old Trafford | |
| 45 | Wed 18 Apr 1979 | League Division One | Nottingham Forest | 1 - 1 | MU | City Ground | |
| 46 | Sat 21 Apr 1979 | League Division One | Tottenham Hotspur | 1 - 1 | MU | White Hart Lane | |
| 47 | Wed 25 Apr 1979 | League Division One | MU | 1 - 0 | Norwich City | Old Trafford | |
| 48 | Sat 28 Apr 1979 | League Division One | MU | 0 - 0 | Derby County | Old Trafford | |
| 49 | Mon 30 Apr 1979 | League Division One | Southampton | 1 - 1 | MU | The Dell | |
| 50 | Sat 5 May 1979 | League Division One | West Bromwich Albion | 1 - 0 | MU | The Hawthorns | |
| 51 | Mon 7 May 1979 | League Division One | MU | 3 - 2 | Wolverhampton Wanderers | Old Trafford | |
| 52 | Sat 12 May 1979 | FA Cup | MU * | 2 - 3 | Arsenal | Wembley | |
| 53 | Wed 16 May 1979 | League Division One | MU | 1 - 1 | Chelsea | Old Trafford |
In the tables above and below, where MU * (or NH *) appears in the home team column, it indicates a match played at a neutral venue.
| 1 | Sat 13 Feb 1897 | FA Cup | Southampton | 1 - 1 | NH | County Cricket Ground | |
| 2 | Wed 17 Feb 1897 | FA Cup | NH | 3 - 1 | Southampton | Bank Street | |
| 3 | Sat 3 Mar 1923 | League Division Two | MU | 1 - 2 | Southampton | Old Trafford | |
| 4 | Wed 11 Apr 1923 | League Division Two | Southampton | 0 - 0 | MU | The Dell | |
| 5 | Mon 27 Aug 1923 | League Division Two | MU | 1 - 0 | Southampton | Old Trafford | |
| 6 | Mon 3 Sep 1923 | League Division Two | Southampton | 0 - 0 | MU | The Dell | |
| 7 | Sat 18 Oct 1924 | League Division Two | Southampton | 0 - 2 | MU | The Dell | |
| 8 | Wed 22 Apr 1925 | League Division Two | MU | 1 - 1 | Southampton | Old Trafford | |
| 9 | Wed 2 Sep 1931 | League Division Two | MU | 2 - 3 | Southampton | Old Trafford | |
| 10 | Sat 7 May 1932 | League Division Two | Southampton | 1 - 1 | MU | The Dell | |
| 11 | Sat 3 Sep 1932 | League Division Two | Southampton | 4 - 2 | MU | The Dell | |
| 12 | Sat 7 Jan 1933 | League Division Two | MU | 1 - 2 | Southampton | Old Trafford | |
| 13 | Sat 11 Nov 1933 | League Division Two | MU | 1 - 0 | Southampton | Old Trafford | |
| 14 | Sat 24 Mar 1934 | League Division Two | Southampton | 1 - 0 | MU | The Dell | |
| 15 | Tue 1 Jan 1935 | League Division Two | MU | 3 - 0 | Southampton | Old Trafford | |
| 16 | Mon 22 Apr 1935 | League Division Two | Southampton | 1 - 0 | MU | The Dell | |
| 17 | Sat 28 Sep 1935 | League Division Two | Southampton | 2 - 1 | MU | The Dell | |
| 18 | Sat 1 Feb 1936 | League Division Two | MU | 4 - 0 | Southampton | Old Trafford | |
| 19 | Sat 25 Sep 1937 | League Division Two | MU | 1 - 2 | Southampton | Old Trafford | |
| 20 | Sat 5 Feb 1938 | League Division Two | Southampton | 3 - 3 | MU | The Dell | |
| 21 | Sat 27 Apr 1963 | FA Cup | MU * | 1 - 0 | Southampton | Villa Park | |
| 22 | Sat 4 Jan 1964 | FA Cup | Southampton | 2 - 3 | MU | The Dell | |
| 23 | Sat 19 Nov 1966 | League Division One | Southampton | 1 - 2 | MU | The Dell | |
| 24 | Tue 18 Apr 1967 | League Division One | MU | 3 - 0 | Southampton | Old Trafford | |
| 25 | Sat 18 Nov 1967 | League Division One | MU | 3 - 2 | Southampton | Old Trafford | |
| 26 | Sat 13 Apr 1968 | League Division One | Southampton | 2 - 2 | MU | The Dell | |
| 27 | Sat 19 Oct 1968 | League Division One | MU | 1 - 2 | Southampton | Old Trafford | |
| 28 | Sat 21 Dec 1968 | League Division One | Southampton | 2 - 0 | MU | The Dell | |
| 29 | Sat 16 Aug 1969 | League Division One | MU | 1 - 4 | Southampton | Old Trafford | |
| 30 | Wed 8 Oct 1969 | League Division One | Southampton | 0 - 3 | MU | The Dell | |
| 31 | Sat 21 Nov 1970 | League Division One | Southampton | 1 - 0 | MU | The Dell | |
| 32 | Sat 20 Feb 1971 | League Division One | MU | 5 - 1 | Southampton | Old Trafford | |
| 33 | Sat 27 Nov 1971 | League Division One | Southampton | 2 - 5 | MU | The Dell | |
| 34 | Sat 15 Jan 1972 | FA Cup | Southampton | 1 - 1 | MU | The Dell | |
| 35 | Wed 19 Jan 1972 | FA Cup | MU | 4 - 1 | Southampton | Old Trafford | |
| 36 | Sat 15 Apr 1972 | League Division One | MU | 3 - 2 | Southampton | Old Trafford | |
| 37 | Sat 25 Nov 1972 | League Division One | MU | 2 - 1 | Southampton | Old Trafford | |
| 38 | Sat 31 Mar 1973 | League Division One | Southampton | 0 - 2 | MU | The Dell | |
| 39 | Sat 8 Dec 1973 | League Division One | MU | 0 - 0 | Southampton | Old Trafford | |
| 40 | Sat 20 Apr 1974 | League Division One | Southampton | 1 - 1 | MU | The Dell | |
| 41 | Sat 26 Oct 1974 | League Division Two | MU | 1 - 0 | Southampton | Old Trafford | |
| 42 | Sat 5 Apr 1975 | League Division Two | Southampton | 0 - 1 | MU | The Dell | |
| 43 | Sat 1 May 1976 | FA Cup | MU * | 0 - 1 | Southampton | Wembley | |
| 44 | Sat 26 Feb 1977 | FA Cup | Southampton | 2 - 2 | MU | The Dell | |
| 45 | Tue 8 Mar 1977 | FA Cup | MU | 2 - 1 | Southampton | Old Trafford | |
| 46 | Sat 4 Nov 1978 | League Division One | MU | 1 - 1 | Southampton | Old Trafford | |
| 47 | Mon 30 Apr 1979 | League Division One | Southampton | 1 - 1 | MU | The Dell | |
| 48 | Sat 18 Aug 1979 | League Division One | Southampton | 1 - 1 | MU | The Dell | |
| 49 | Sat 10 Nov 1979 | League Division One | MU | 1 - 0 | Southampton | Old Trafford | |
| 50 | Sat 29 Nov 1980 | League Division One | MU | 1 - 1 | Southampton | Old Trafford | |
| 51 | Sat 7 Mar 1981 | League Division One | Southampton | 1 - 0 | MU | The Dell | |
| 52 | Sat 5 Dec 1981 | League Division One | Southampton | 3 - 2 | MU | The Dell | |
| 53 | Sat 1 May 1982 | League Division One | MU | 1 - 0 | Southampton | Old Trafford | |
| 54 | Sat 18 Sep 1982 | League Division One | Southampton | 0 - 1 | MU | The Dell | |
| 55 | Wed 1 Dec 1982 | League Cup | MU | 2 - 0 | Southampton | Old Trafford | |
| 56 | Sat 9 Apr 1983 | League Division One | MU | 1 - 1 | Southampton | Old Trafford | |
| 57 | Sat 17 Sep 1983 | League Division One | Southampton | 3 - 0 | MU | The Dell | |
| 58 | Sat 21 Jan 1984 | League Division One | MU | 3 - 2 | Southampton | Old Trafford | |
| 59 | Tue 28 Aug 1984 | League Division One | Southampton | 0 - 0 | MU | The Dell | |
| 60 | Wed 24 Apr 1985 | League Division One | MU | 0 - 0 | Southampton | Old Trafford | |
| 61 | Sat 28 Sep 1985 | League Division One | MU | 1 - 0 | Southampton | Old Trafford | |
| 62 | Sat 1 Mar 1986 | League Division One | Southampton | 1 - 0 | MU | The Dell | |
| 63 | Sat 13 Sep 1986 | League Division One | MU | 5 - 1 | Southampton | Old Trafford | |
| 64 | Wed 29 Oct 1986 | League Cup | MU | 0 - 0 | Southampton | Old Trafford | |
| 65 | Tue 4 Nov 1986 | League Cup | Southampton | 4 - 1 | MU | The Dell | |
| 66 | Sat 3 Jan 1987 | League Division One | Southampton | 1 - 1 | MU | The Dell | |
| 67 | Sat 15 Aug 1987 | League Division One | Southampton | 2 - 2 | MU | The Dell | |
| 68 | Sat 16 Jan 1988 | League Division One | MU | 0 - 2 | Southampton | Old Trafford | |
| 69 | Sat 19 Nov 1988 | League Division One | MU | 2 - 2 | Southampton | Old Trafford | |
| 70 | Sat 6 May 1989 | League Division One | Southampton | 2 - 1 | MU | The Dell | |
| 71 | Sat 28 Oct 1989 | League Division One | MU | 2 - 1 | Southampton | Old Trafford | |
| 72 | Sat 24 Mar 1990 | League Division One | Southampton | 0 - 2 | MU | The Dell | |
| 73 | Sat 22 Sep 1990 | League Division One | MU | 3 - 2 | Southampton | Old Trafford | |
| 74 | Wed 16 Jan 1991 | League Cup | Southampton | 1 - 1 | MU | The Dell | |
| 75 | Wed 23 Jan 1991 | League Cup | MU | 3 - 2 | Southampton | Old Trafford | |
| 76 | Wed 13 Mar 1991 | League Division One | Southampton | 1 - 1 | MU | The Dell | |
| 77 | Sat 14 Sep 1991 | League Division One | Southampton | 0 - 1 | MU | The Dell | |
| 78 | Mon 27 Jan 1992 | FA Cup | Southampton | 0 - 0 | MU | The Dell | |
| 79 | Wed 5 Feb 1992 | FA Cup | MU | 2 - 2 | Southampton | Old Trafford | |
| 80 | Thu 16 Apr 1992 | League Division One | MU | 1 - 0 | Southampton | Old Trafford | |
| 81 | Mon 24 Aug 1992 | Premiership | Southampton | 0 - 1 | MU | The Dell | |
| 82 | Sat 20 Feb 1993 | Premiership | MU | 2 - 1 | Southampton | Old Trafford | |
| 83 | Sat 28 Aug 1993 | Premiership | Southampton | 1 - 3 | MU | The Dell | |
| 84 | Wed 4 May 1994 | Premiership | MU | 2 - 0 | Southampton | Old Trafford | |
| 85 | Sat 31 Dec 1994 | Premiership | Southampton | 2 - 2 | MU | The Dell | |
| 86 | Wed 10 May 1995 | Premiership | MU | 2 - 1 | Southampton | Old Trafford | |
| 87 | Sat 18 Nov 1995 | Premiership | MU | 4 - 1 | Southampton | Old Trafford | |
| 88 | Mon 11 Mar 1996 | FA Cup | MU | 2 - 0 | Southampton | Old Trafford | |
| 89 | Sat 13 Apr 1996 | Premiership | Southampton | 3 - 1 | MU | The Dell | |
| 90 | Sat 26 Oct 1996 | Premiership | Southampton | 6 - 3 | MU | The Dell | |
| 91 | Sat 1 Feb 1997 | Premiership | MU | 2 - 1 | Southampton | Old Trafford | |
| 92 | Wed 13 Aug 1997 | Premiership | MU | 1 - 0 | Southampton | Old Trafford | |
| 93 | Mon 19 Jan 1998 | Premiership | Southampton | 1 - 0 | MU | The Dell | |
| 94 | Sat 3 Oct 1998 | Premiership | Southampton | 0 - 3 | MU | The Dell | |
| 95 | Sat 27 Feb 1999 | Premiership | MU | 2 - 1 | Southampton | Old Trafford | |
| 96 | Sat 25 Sep 1999 | Premiership | MU | 3 - 3 | Southampton | Old Trafford | |
| 97 | Sat 22 Apr 2000 | Premiership | Southampton | 1 - 3 | MU | The Dell | |
| 98 | Sat 28 Oct 2000 | Premiership | MU | 5 - 0 | Southampton | Old Trafford | |
| 99 | Sun 13 May 2001 | Premiership | Southampton | 2 - 1 | MU | The Dell | |
| 100 | Sat 22 Dec 2001 | Premiership | MU | 6 - 1 | Southampton | Old Trafford | |
| 101 | Sun 13 Jan 2002 | Premiership | Southampton | 1 - 3 | MU | St Mary's Stadium | |
| 102 | Sat 2 Nov 2002 | Premiership | MU | 2 - 1 | Southampton | Old Trafford | |
| 103 | Sat 1 Feb 2003 | Premiership | Southampton | 0 - 2 | MU | St Mary's Stadium | |
| 104 | Sun 31 Aug 2003 | Premiership | Southampton | 1 - 0 | MU | St Mary's Stadium | |
| 105 | Sat 31 Jan 2004 | Premiership | MU | 3 - 2 | Southampton | Old Trafford | |
| 106 | Sat 4 Dec 2004 | Premiership | MU | 3 - 0 | Southampton | Old Trafford | |
| 107 | Sat 12 Mar 2005 | FA Cup | Southampton | 0 - 4 | MU | St Mary's Stadium | |
| 108 | Sun 15 May 2005 | Premiership | Southampton | 1 - 2 | MU | St Mary's Stadium | |
| 109 | Sun 4 Jan 2009 | FA Cup | Southampton | 0 - 3 | MU | St Mary's Stadium |